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Post-Meal Patterns
Pre Bolusing: The Juicebox Way
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Understanding TSA

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Episode 1,827 · Apr 17, 2026 Interview Type 1 Diabetes

From ACEs to PACEs: The Science of Rewiring the Developing Brain

A four-part series on the powerful impact of early stress on brain development and long-term life outcomes. Hear science-based strategies for leveraging positive, protective, and compensatory experiences (PACEs) to foster healing and build enduring resilience within the diabetes community.

Key Takeaways
  • Brain development and stress. Early toxic stress can alter neurological systems, making the amygdala oversensitive and weakening the prefrontal cortex.
  • ACE study results. High Adverse Childhood Experience scores are statistically linked to higher risks of chronic disease, depression, and reduced life expectancy.
  • The power of resilience. A high ACE score is not a destiny — positive experiences can buffer stress and rewire brain circuitry.
  • Predictable connections. Simple, consistent actions — being present, focused eye contact, physical touch — build lasting trust and security.
  • Diabetes and adversity. Families living with type 1 can intentionally build PACEs to offset the emotional and physical burden of the condition.
Transcript Preview

Scott Benner 0:00 Hello, friends, and welcome back to another episode of the Juicebox Podcast. Welcome to the first episode of my PACEs series with Erika Forsyth. This series is about something very powerful — the experiences that shape our brains and our lives.

Scott Benner 0:32 Research from the landmark ACE study showed that early stress can affect how the brain develops and how our bodies respond to the world. But newer research adds something equally important — positive experiences can build resilience and help heal those effects.

Scott Benner 2:14 Erika, the other day I sent you a note, and I said, we talk about the ACEs sometimes — is there something opposite of the ACEs? I went to the internet to try to figure it out, and then I just threw it in your lap.

Erika Forsyth 3:03 Great. So, well, lo and behold, even in your inquiry and thought — those things, these lists, these studies do exist. We are going to talk about the opposite of the ACEs. I think it might be helpful to start with reviewing the ACEs study first.

Scott Benner 3:42 I think that's terrific. And can you please tease here a little bit that maybe it isn't as black and white as these things happen to you, so you're going to have positive outcomes — or these things happen to you and you're gonna have negative outcomes. There's also maybe more of a gray area?

Read full transcript → All 1,827 episodes
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Apr 1, 2026

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Feb 24, 2026

Join the SEMPA Trial for Type 1 Diabetes and AID Systems

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Nov 29, 2025

Why Your Carb Ratio Stopped Working (And Why It's Not Your Fault)

The one thing nobody tells you about why your ratios drift — and what to do.

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